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PCV2感染后JAK-STAT信号通路的基因差异表达分析

点击数:2762  时间:2019-10-24 15:22:27  来源: 信息处      作者: 时建立,彭 喆,吴晓燕 等

JAK-STAT信号通路是阐明细胞因子生物学功能及病毒如何发挥作用的分子基础,但对于猪圆环病毒2型(PCV2)感染及病毒复制的作用机制,目前尚无报道。本研究采用PCR列阵方法,建立PK-15细胞JAK-STAT信号通路的功能分类芯片,分析JAK-STAT信号通路中所有已知的JakStat家族成员、激活JAK-STAT信号通路的受体,以及与Stat蛋白相关的核辅助因子及共同活化因子、Stat诱导蛋白及该通路的负反馈调节蛋白等基因在PCV2感染后的差异表达情况,为进一步明确PK-15细胞JAK-STAT信号通路对病毒复制力和复制机制奠定基础。

Analysis onDifferential Gene Expression of JAK-STATSignaling Pathway after PCV2 Infection

The JAK-STATsignaling pathway could help us to expound biological function of cytokines andhow viruses workbut the infection with porcinecircovirus type 2PCV2and virus replication mechanism havenot been reported so far. In this studyPCR array wasused to establish a functional taxonomic chip of the JAK-STAT pathway in PK-15cellsthen the differential gene expressionof the pathway after PCV2 infection were analyzedincluding allknown Jak and Stat family membersreceptorsactivating the pathwaynuclearcofactors and coactivators related to Stat proteinStat-inducible protein and negativeregulatory proteinswhich wouldlay a foundation for further identifying how the pathway influence virusreplication and replication mechanism.

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